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IgE in serum

Reference interval: 1) 3-423 IU/mL, age > 17 (median 40 IU/mL), 0-158 IU/mL (VA) 2) 1% of maternal value at term 3) 1.1-10.2 IU/mL, age = 1 year 4) 2.4-34.8 IU/mL. age = 4 years 5) 0.3-215 IU/mL, age = 10 years (mean 24 IU/mL) Increases: 1) parasitic infections 2) allergic bronchopulmonary aspergillosis 3) pharmaceutical agents: especially gold compounds 4) atopic diseases 5) eczema 6) asthma (60%) 7) hay fever (30%) 8) hyperimmunoglobulin E syndrome* 9) Wiskott Aldrich syndrome 10) IgE myeloma 11) IgA deficiency * serum levels of IgE may be determined by polymorphisms in PHF11 gene Methods: - RIA & PRIST (paper radioimmunosorbant test) Specimen: 1) serum 2) fresh or store at 4 degrees C for < 72 hours 3) stable frozen at -20 degrees C for 6 months 4) stable frozen at -70 degrees C indefinitely Notes: - Measurement of total IgE can be misleading - Patient with IgE antibodies to specific allergens may have total IgE serum levels within normal limits.

Related

hyperimmunoglobulin E (Job's syndrome) immunoglobulin-E (IgE) PHD finger protein 11; BRCA1 C-terminus-associated protein; renal carcinoma antigen NY-REN-34 (PHF11 BCAP) radioimmunoassay (RIA)

General

immunoglobulin in serum IgE in body fluid

Database Correlations

OMIM 147050

References

  1. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  2. Mini Panel of 2 tests: Immunofixation IgD . Immunofixation IgE Laboratory Test Directory ARUP: 50049
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