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immunoglobulin-D (IgD)

Function: - IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM - membrane-bound IgD (mIgD) induces phosphorylation of CD79A & CD79B by the Src family of protein tyrosine kinases - soluble IgD (sIgD) concentration in serum is below those of IgG, IgA, & IgM but much higher than that of IgE - IgM & IgD molecules present on B cells have identical V regions & antigen-binding sites - after the antigen binds to the B cell receptor, the secreted form sIgD is shut off - IgD is a potent inducer of TNF, IL1B, & IL1RN - IgD also induces release of IL6, IL10, & LIF from monocytes - kappa light chains are found predominantly on the membrane IgD (mIgD) form & lambda on the secreted IgD (sIgD) form - membrane-bound IgD molecules are non-covalently associated with a heterodimer of CD79A & CD79B - associates with/activates blk, lyn, fyn, hck, & lck [1] & Syk [2]

Related

IgD Ag in tissue IgD in serum

General

adhesion receptor cell surface immunoglobulin

Properties

SIZE: MW = 170 kD COMPARTMENT: plasma membrane CELL: B lymphocyte plasma cell MOTIF: ligand-binding site transmembrane domain SECRETED-BY: plasma cell SUBUNITS: immunoglobulin delta chain (Ig-delta) (2) MOTIF: Ig heavy chain variable region NAME: Ig heavy chain variable region heavy chain constant region-1 MOTIF: cysteine residue {CH1.SITE1} MODIFICATION: cysteine residue {CH1.SITE2} cysteine residue {CH1.SITE2} MODIFICATION: cysteine residue {CH1.SITE1} cysteine residue {C-TO-CH1} MODIFICATION: cysteine residue {C-TO-CL} hinge region MOTIF: cysteine residue {HINGE1} MODIFICATION: cysteine residue {HINGE1} cysteine residue {HINGE2} MODIFICATION: cysteine residue {HINGE2} heavy chain constant region-2 MOTIF: cysteine residue {CH2.SITE1} MODIFICATION: cysteine residue {CH2.SITE2} cysteine residue {CH2.SITE2} MODIFICATION: cysteine residue {CH2.SITE1} heavy chain constant region-3 MOTIF: cysteine residue {CH3.SITE1} MODIFICATION: cysteine residue {CH3.SITE2} cysteine residue {CH3.SITE2} MODIFICATION: cysteine residue {CH3.SITE1} transmembrane domain immunoglobulin light chain (2) MOTIF: Ig light chain variable region NAME: Ig light chain variable region light chain constant region MOTIF: cysteine residue {CLSITE1} MODIFICATION: cysteine residue {CL.SITE2} cysteine residue {CL.SITE2} MODIFICATION: cysteine residue {CL.SITE1} cysteine residue {C-TO-CL} MODIFICATION: cysteine residue {C-TO-CH1} MISC-INFO: CONCENTRATION 10-40 MG/DL

References

  1. Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: 1281458
  2. DeFranco AL, Law DA. Tyrosine phosphatases and the antibody response. Science. 1995 Apr 14;268(5208):263-4. Review. PMID: 7716518
  3. UniProt :accession P0DOX3
  4. PubMed refs - PMID: 22158414 - PMID: 20176268 - PMID: 8774350 - PMID: 10702483 - PMID: 702483 - PMID: 16895553 - PMID: 895553 - PMID: 176268 - PMID: 11282392

Components

immunoglobulin delta chain (Ig-delta) immunoglobulin light chain