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immunoglobulin-binding protein 1; CD79a-binding protein 1; B-cell signal transduction molecule alpha 4; protein alpha-4; renal carcinoma antigen NY-REN-16 (IGBP1, IBP1)
Function:
- associated with surface IgM-receptor
- may be involved in signal transduction
- may be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases
- phosphorylated (putative)
- associates with PP2A-alpha & PP2A-beta catalytic subunits, & with PP4 & PP6. interacts with MID1 & MID2
Structure: belongs to the IGBP1/TAP42 family
Compartment: cytoplasm (putative)
Expression:
- ubiquitously expressed with highest levels in heart, skeletal muscle & pancreas
Pathology:
- defects in IGBP1 are the cause of agenesis of the corpus callosum with mental retardation, ocular coloboma & micrognathia
General
phosphoprotein
Properties
SIZE: entity length = 339 aa
MW = 39 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
phosphorylation site
Database Correlations
OMIM correlations
UniProt P78318
Pfam PF04177
Entrez Gene 3476
Kegg hsa:3476
References
UniProt :accession P78318