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IgA pemphigus
Pathology:
- subcorneal neutrophils
- epidermal acantholysis
- tissue-bound & circulating IgA autoantibodies that target desmosomal proteins
- deposits of intercellular IgA at epidermal surfaces
* histopathology images [2]
Clinical manifestations:
- vesiculopustular eruption
- formation of clear blisters that rapidly become pustules
- distribution:
- trunk & proximal extremities
- relative sparing of mucous membranes
Laboratory:
- direct immunofluorescence
Differential diagnosis:
- linear IgA bullous dermatosis (IgA pemphigoid)
Related
linear IgA bullous dermatosis (IgA pemphigoid)
General
pemphigus
References
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
- Sandhu N, Elston DM (images)
Medscape: IgA Pemphigus
http://emedicine.medscape.com/article/1063776-overview