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immunoglobulin-A (IgA)
IgA is the dominant immunoglobulin of the mucosal immune system providing the main defense for mucosal surfaces. IgA is made in lymphoid tissues that are proximal to mucosa-bearing organs & is transported onto mucosal surfaces. IgA molecules in blood are not secreted onto mucosal surfaces.
Laboratory:
- IgA in skin
- IgA in body fluid
- IgA in CSF
- IgA in peritoneal fluid
- IgA in saliva
- IgA in serum
- IgA in urine
- IgA secretory in body fluid
- IgA secretory in saliva
- IgA secretory in serum/plasma
- IgA secretory in sweat
- IgA secretory in tears
- IgA monoclonal in CSF
- IgA monoclonal in serum
Related
IgA in body fluid
linear IgA disease
selective IgA deficiency
General
immunoglobulin
Properties
SIZE: MW = 180 kD
COMPARTMENT:
plasma
SECRETED-BY:
plasma cell
SUBUNITS:
immunoglobulin alpha chain (Ig-alpha) (2)
MOTIF: Ig heavy chain variable region
NAME: Ig heavy chain variable region
heavy chain constant region-1
MOTIF: cysteine residue {CH1.SITE1}
MODIFICATION: cysteine residue {CH1.SITE2}
cysteine residue {CH1.SITE2}
MODIFICATION: cysteine residue {CH1.SITE1}
cysteine residue {C-TO-CH1}
MODIFICATION: cysteine residue {C-TO-CL}
hinge region
MOTIF: cysteine residue {HINGE1}
MODIFICATION: cysteine residue {HINGE1}
cysteine residue {HINGE2}
MODIFICATION: cysteine residue {HINGE2}
heavy chain constant region-2
MOTIF: cysteine residue {CH2.SITE1}
MODIFICATION: cysteine residue {CH2.SITE2}
cysteine residue {CH2.SITE2}
MODIFICATION: cysteine residue {CH2.SITE1}
heavy chain constant region-3
MOTIF: cysteine residue {CH3.SITE1}
MODIFICATION: cysteine residue {CH3.SITE2}
cysteine residue {CH3.SITE2}
MODIFICATION: cysteine residue {CH3.SITE1}
immunoglobulin light chain (2)
MOTIF: Ig light chain variable region
NAME: Ig light chain variable region
light chain constant region
MOTIF: cysteine residue {CLSITE1}
MODIFICATION: cysteine residue {CL.SITE2}
cysteine residue {CL.SITE2}
MODIFICATION: cysteine residue {CL.SITE1}
cysteine residue {C-TO-CL}
MODIFICATION: cysteine residue {C-TO-CH1}
immunoglobulin J chain (Ig-J)
MISC-INFO: CONCENTRATION 40-350 MG/DL
References
Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
Components
immunoglobulin alpha chain (Ig-alpha)
immunoglobulin J chain (Ig-J)
immunoglobulin light chain