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interferon beta; IFN-beta; fibroblast interferon (IFNB1, IFB, IFNB)

Function: - antiviral, antibacterial & anticancer activities Structure: - monomer - belongs to the alpha/beta interferon family Compartment: secreted Pharmacology: - available under the names Avonex (Biogen), Betaseron (Berlex) & Rebif (Serono) - used in the treatment of multiple sclerosis (MS) - Betaseron is a slightly modified form of IFNB1 with two residue substitutions Laboratory: - interferon beta in serum/plasma - interferon beta Ab in serum/plasma - interferon beta IgG in serum/plasma

Related

interferon [IFN]-beta gene

Specific

interferon [IFN]-beta 1A (Avonex) interferon [IFN]-beta 1B (betaseron, Extavia) interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; hybridoma growth factor; interferon beta-2; IFN-beta-2 (IL6, IFNB2)

General

interferon

Properties

SIZE: entity length = 187 aa MW = 22 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} cysteine residue {C52} MODIFICATION: cysteine residue {C162} N-glycosylation site {N101} Ser phosphorylation site {S140} cysteine residue {C162} MODIFICATION: cysteine residue {C52} SECRETED-BY: fibroblast

Database Correlations

OMIM 147640 UniProt P01574 Pfam PF00143 Entrez Gene 3456 Kegg hsa:3456

References

  1. UniProt :accession P01574
  2. Avonex; Note: Clinical information on Avonex http://www.avonex.com/index.xml
  3. Betaseron; Note: Clinical information on Betaseron http://www.betaseron.com/index.jsp
  4. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908