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interferon (IFN)-alpha/beta receptor beta chain; interferon alpha/beta receptor 2; IFN-alpha-REC; type I interferon receptor; IFN-R (IFNAR2, IFNABR, IFNARB)
Function:
- receptor for interferons alpha & beta
- isoform 1 & isoform 3 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1
- isoform 1 also interacts with transcriptional factors, STAT1 & STAT2
- both isoforms are potent inhibitors of type 1 IFN activity upon binding
- phosphorylated on Tyr
Structure: belongs to the type II cytokine receptor family
Compartment: membrane; Single-pass type I membrane protein
Alternative splicing: named isoforms=3
Pathology:
- defects in IFNAR2 are associated with susceptibility to hepatitis B virus infection
General
glycoprotein
interferon receptor
Properties
SIZE: entity length = 515 aa
MW = 58 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
cysteine residue {C39}
MODIFICATION: cysteine residue {C122}
N-glycosylation site {N58}
cysteine residue {C85}
MODIFICATION: cysteine residue {C93}
N-glycosylation site {N87}
cysteine residue {C93}
MODIFICATION: cysteine residue {C85}
N-glycosylation site {N116}
cysteine residue {C122}
MODIFICATION: cysteine residue {C39}
N-glycosylation site {N188}
N-glycosylation site {N192}
cysteine residue {C207}
MODIFICATION: cysteine residue {C227}
cysteine residue {C227}
MODIFICATION: cysteine residue {C207}
transmembrane domain {244-264}
binding site
FOR-BINDING-OF: Janus kinase (JAK)
Database Correlations
OMIM correlations
MORBIDMAP 602376
UniProt P48551
Pfam PF09294
Kegg hsa:3455
References
- UniProt :accession P48551
- SeattleSNPs
http://pga.gs.washington.edu/data/ifnar2/
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- Ihle JN et al
Signaling by the cytokine receptor superfamily: JAKs and STATs
TIBS 19:222 1994
PMID: 8048164
Component-of
interferon [IFN] alpha/beta receptor