Search
stress-induced-phosphoprotein 1; STI1; Hsc70/Hsp90-organizing protein; Hop; transformation-sensitive protein IEF SSP 3521; NY-REN-11 antigen (STIP1)
Function:
- mediates the association of the molecular chaperones HSC70 & HSP90 (HSPCA & HSPCB)
- forms a complex with HSC70 & HSPCA/HSP-86 & HSPCB/HSP-84
- interacts with PACRG
Structure:
- the TPR repeat 1 interacts with the C-terminal of HSC70
- the TPR repeats 4, 5 & 6 (also called TPR2A domain) & TPR repeats 7, 8 & 9 (also called TPR2B domain) interact with HSP90
- contains 2 STI1 domains
- contains 9 TPR repeats
Compartment:
- cytoplasm (putative)
- nucleus
General
phosphoprotein
Properties
SIZE: entity length = 543 aa
MW = 63 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
tetratricopeptide repeat {4-37}
MOTIF: Ser phosphorylation site {S16}
tetratricopeptide repeat {38-71}
tetratricopeptide repeat {72-105}
STI1 1 {130-169}
Thr phosphorylation site {T198}
nuclear translocation signal {222-239}
tetratricopeptide repeat {225-258}
tetratricopeptide repeat {259-292}
tetratricopeptide repeat {300-333}
Tyr phosphorylation site {Y354}
tetratricopeptide repeat {360-393}
tetratricopeptide repeat {394-427}
tetratricopeptide repeat {428-461}
Ser phosphorylation site {S481}
STI1 2 {492-531}
Database Correlations
OMIM 605063
UniProt P31948
Pfam PF00515
Entrez Gene 10963
Kegg hsa:10963
References
UniProt :accession P31948