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idoxuridine ophthalmic (Herplex, Stoxil)

Tradenames: Herplex, Stoxil. Indications: treatment of Herpes simplex keratitis Dosage: 1) 1 drop into affected eye every hour during day & every 2 hours at night, until improvement 2) then, 1 drop every 2 hours during day & every 4 hours at night 3) continue for 5-7 days after healing 4) recurrences are more likely to occur is treatment is not continues 3-7 days after healing appears complete 5) if no response in 14 days, consider another agent Ointment: 0.5% (4 g) Adverse effects: 1) not common (1-10%) - pruritus, follicular conjunctivitis, irritation, pain, inflammation, mild edema of the eyelids & cornea, visual haze, corneal clouding, photophobia 2) uncommon (< 1%) - small punctate defects on the corneal epithelium Drug interactions: - boric acid-containing solutions in combination may result in formation of a precipitate Mechanism of action: - replaces thymidine in normal viral DNA structure resulting in mutation & inhibition of viral replication

General

idoxuridine (IDU, IUDR) ophthalmic antiviral

Properties

MISC-INFO: pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998