idiopathic primary hypothyroidism; atrophic autoimmune thyroiditis

The most frequent cause of hypothyroidism in the US. Etiology: blocking antibodies against TSH receptor Genetics: association with HLA-DR3 & HLA-B8. Management: - thyroxine (thyroid hormone replacement) Prognosis: - auto-antibody may disappear spontaneously or with treatment

General

thyroiditis hypothyroidism

References

Cotran et al Robbins Pathologic Basis of Disease, 5th ed. W.B. Saunders Co, Philadelphia, PA 1994 pg 1125-26