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idalopirdine
Contraindications:
- Alzheimer's disease
* idalopirdine failed to slow cognitive decline in patients with Alzheimer's disease in phase 3 trial [1]
* of no benefit added to a cholinesterase inhibitor [2,3]
Mechanism of action:
- serotonin receptor antagonist
- 5HT6 receptor antagonist
General
serotonin antagonist
Database Correlations
PUBCHEM cid=21071390
References
- Fiore K
NeuroBreak: Alzheimer's Drug Bombs; Elephant Tranquilizer ODs.
MEDPAGE TODAY. Sept 27, 2016
http://www.medpagetoday.com/Neurology/GeneralNeurology/60482
- Fiore K
AAIC 2017 Meeting Coverage. 5HT6 Blocker a Dud in Alzheimer
Trials - May shake confidence in similar drugs being developed.
https://www.medpagetoday.com/MeetingCoverage/AAIC/66784
- Atri A, Frolich L, Ballard C et al
Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors
on Change in Cognition in Patients With Alzheimer Disease.
Three Randomized Clinical Trials.
JAMA. 2018;319(2):130-142
PMID: 29318278
https://jamanetwork.com/journals/jama/article-abstract/2668349
- Bennett DA
Lack of Benefit With Idalopirdine for Alzheimer Disease.
Another Therapeutic Failure in a Complex Disease Process.
JAMA. 2018;319(2):123-125. Jan 9.
PMID: 29318261
https://jamanetwork.com/journals/jama/article-abstract/2668332