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intercellular adhesion molecule 1; ICAM-1; major group rhinovirus receptor; CD54 (ICAM1)
Function:
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)
- role in adhesion of leukocytes to endothelium during inflammation.
- during leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF & RHOG activation
- monoubiquitinated, which is promoted by MARCH9 & leads to endocytosis
- interacts with MUC1 & promotes cell aggregation in epithelial cells
- interacts with SGEF
Structure:
- homodimer (probable)
- MW depends upon degree of glycosylation
- belongs to the immunoglobulin superfamily, ICAM family
- contains 5 Ig-like C2-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- B & T cells
- monocytes
- endothelial cells
- normally expressed in low levels on cerebral endothelial cells
- epithelial cells
- expression induced by IL-1, IL-6, IFN-gamma, TNF
Polymorphism:
- homozygotes with ICAM1-kalifi Met-56 seem to have an increased risk for cerebral malaria
Pathology:
- major group rhinovirus receptor
- interacts with human herpesvirus 8 MIR2 protein (probable)
- binds to coxsackievirus A21 capsid proteins & acts as a receptor for this virus
- accumulates in senile plaques of Alzheimer's disease
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
intercellular adhesion molecule (ICAM)
Properties
SIZE: entity length = 532 aa
MW = 58 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-27}
immunoglobulin superfamily domain {41-103}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C92}
cysteine residue {C52}
MODIFICATION: cysteine residue {C96}
cysteine residue {C92}
MODIFICATION: cysteine residue {C48}
cysteine residue {C96}
MODIFICATION: cysteine residue {C52}
immunoglobulin superfamily domain {128-193}
MOTIF: N-glycosylation site {N130}
cysteine residue {C135}
MODIFICATION: cysteine residue {C186}
N-glycosylation site {N145}
Cell attachment site; atypical {152-154}
N-glycosylation site {N183}
cysteine residue {C186}
MODIFICATION: cysteine residue {C135}
N-glycosylation site {N202}
immunoglobulin superfamily domain {230-297}
MOTIF: cysteine residue {C237}
MODIFICATION: cysteine residue {C290}
N-glycosylation site {N267}
cysteine residue {C290}
MODIFICATION: cysteine residue {C237}
N-glycosylation site {N296}
immunoglobulin superfamily domain {325-378}
MOTIF: cysteine residue {C332}
MODIFICATION: cysteine residue {C371}
cysteine residue {C371}
MODIFICATION: cysteine residue {C332}
N-glycosylation site {N385}
cysteine residue {C403}
MODIFICATION: cysteine residue {C419}
N-glycosylation site {N406}
immunoglobulin superfamily domain {412-464}
MOTIF: cysteine residue {C419}
MODIFICATION: cysteine residue {C403}
cysteine residue {C431}
MODIFICATION: cysteine residue {C457}
cysteine residue {C457}
MODIFICATION: cysteine residue {C431}
transmembrane domain {481-503}
Database Correlations
OMIM 147840
MORBIDMAP 147840
UniProt P05362
Pfam PF03921
Entrez Gene 3383
Kegg hsa:3383
References
- Akella R, Hall RE.
Expression of the adhesion molecules ICAM-1 and ICAM-2 on
tumor cell lines does not correlate with their susceptibility
to natural killer cell-mediated cytolysis: evidence for
additional ligands for effector cell beta integrins.
Eur J Immunol. 1992 Apr;22(4):1069-74.
PMID: 1348028
- Verbeek MM, Otte-Holler I, Westphal JR, Wesseling P et al
Accumulation of intercellular adhesion molecule-1 in senile
plaques in brain tissue of patients with Alzheimer's disease.
Am J Pathol. 1994 Jan;144(1):104-16.
PMID: 7904796
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 3383
- Wikipedia; Note: intercellular adhesion molecule entry
http://en.wikipedia.org/wiki/intercellular_adhesion_molecule
- SeattleSNPs
http://pga.gs.washington.edu/data/icam1/
- virus particle exploreR db; Note: Icosahedral capsid
structure
http://viperdb.scripps.edu/info_page.php?VDB=1z7z
- Functional glycomics gateway - glycan binding; Note: ICAM-1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_261
- UniProt :accession P05362