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CD102; intercellular adhesion molecule 2; ICAM-2 (ICAM2)
Function:
1) ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2
2) mediates adhesive interactions important for
a) antigen-specific immune response
b) NK-cell mediated clearance
c) lymphocyte recirculation via blocking LFA-1-dependent cell adhesion
d) other immune response & surveillance functions
3) adhesion of leukocytes to endothelium during inflammation
Structure:
- belongs to the immunoglobulin superfamily, ICAM family
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- constitutively expressed on surface of endothelial cells, lymphocytes, monocytes, platelets
- some lymphomas
- neutrophils stain negatively with antibody
Related
endothelial cell
lymphocyte
microglia (Hortega cell)
monocyte
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
intercellular adhesion molecule (ICAM)
Properties
SIZE: MW = 31 kD
entity length = 275 aa
COMPARTMENT: plasma membrane
CELL: endothelial cell
lymphocyte*
monocyte
microglia
WITHIN: central nervous system
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {41-98}
MOTIF: N-glycosylation site {N47}
cysteine residue {C48}
MODIFICATION: cysteine residue {C91}
cysteine residue {C52}
MODIFICATION: cysteine residue {C95}
N-glycosylation site {N82}
cysteine residue {C91}
MODIFICATION: cysteine residue {C48}
cysteine residue {C95}
MODIFICATION: cysteine residue {C52}
N-glycosylation site {N105}
immunoglobulin superfamily domain {127-197}
MOTIF: cysteine residue {C134}
MODIFICATION: cysteine residue {C190}
N-glycosylation site {N153}
N-glycosylation site {N176}
N-glycosylation site {N187}
cysteine residue {C190}
MODIFICATION: cysteine residue {C134}
transmembrane domain {224-248}
Database Correlations
OMIM 146630
UniProt P13598
Pfam PF03921
Kegg hsa:3384
References
- Akella R, Hall RE.
Expression of the adhesion molecules ICAM-1 and ICAM-2 on
tumor cell lines does not correlate with their susceptibility
to natural killer cell-mediated cytolysis: evidence for
additional ligands for effector cell beta integrins.
Eur J Immunol. 1992 Apr;22(4):1069-74.
PMID: 1348028
- Verbeek MM, Otte-Holler I, Westphal JR, Wesseling P, Ruiter DJ,
de Waal RM.
Accumulation of intercellular adhesion molecule-1 in senile
plaques in brain tissue of patients with Alzheimer's disease.
Am J Pathol. 1994 Jan;144(1):104-16.
PMID: 7904796
- UniProt :accession P13598
- http://www.pathologyoutlines.com/cd100247.html
21 June 2005
- Functional glycomics gateway - glycan binding; Note: ICAM-2
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_262