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ibandronate; ibandronic acid (Boniva, Bondronat)

Tradename: Boniva (FDA approved 2003) Generic FDA-approved 3/2012 [6] Indications: -> osteoporosis - diminishes risk of vertebral fractures - does not diminish risk of hip fracture [7] Contraindications: 1) renal insufficiency a) creatinine clearance < 30 mL/min b) serum creatinine > 2.3 mg/dL 2) uncorrected hypocalcemia (IV) Pregnancy category: C Dosage: 1) 2.5 mg PO QD [3,4] 2) 150 mg PO monthly [3,4] 3) 3 mg IV every 3 months (infuse over 15-30 seconds) Try to take on same day each month. +/- 1 week OK if average interval is one month [4] Do NOT eat or lie down for 60 minutes after taking monthly Boniva. Prefilled syringe 3mg/3mL Monitor: serum creatinine prior each IV dose Adverse effects: 1) arthralgia (8-9%) 2) back pain (7%) 3) hypertension 5-7% 4) abdominal pain 5-6% 5) GI distress < 5% - dyspepsia, nausea, constipation, diarrhea, gastritis 6) transient hypocalcemia Drug interactions: none reported Mechanism of action: 1) bisphosphonate 2) reduces absolute vertebral fracture risk 5% [4]

Interactions

drug interactions drug adverse effects of bisphosphonates

General

bisphosphonate

Database Correlations

PUBCHEM correlations

References

  1. Prescriber's Letter 11(2):suppl 2004 {Roche}
  2. Prescriber's Letter 11(12): 2004 Boniva (Ibandronate) Coming Soon Detail-Document#: 201204 (subscription needed) http://www.prescribersletter.com
  3. Prescriber's Letter 12(4): 2005 Boniva (Ibandronate) Monthly or Daily Now Available Detail-Document#: 210420 (subscription needed) http://www.prescribersletter.com
  4. Prescriber's Letter 12(5): 2005 New Drug: Ibandronate (Boniva) Detail-Document#: 210510 (subscription needed) http://www.prescribersletter.com
  5. Prescriber's Letter 12(5): 2005 New Formulation: Ibandronate (Boniva) Injection Detail-Document#: 220304 (subscription needed) http://www.prescribersletter.com
  6. Lowes R Medscape: FDA Approves First Generic Boniva for Osteoporosis http://www.medscape.com/viewarticle/760488?sssdmh=dm1.768281&src=nl_newsalert - FDA NEWS RELEASE: March 19, 2012 FDA approves first Boniva generics to treat or prevent osteoporosis http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm296488.htm
  7. Reid IR Efficacy, effectiveness and side effects of medications used to prevent fractures. J Intern Med. 2015 Jun;277(6):690-706 PMID: 25495429
  8. Boniva prescribing information http://www.gene.com/gene/products/information/boniva/pdf/boniva_prescribing_tablets.pdf