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IKB protein

Function: - IkB binds to the p65 subunit of NF-kappa B, inhibiting transcriptional activity of NF-kappa B by retaining it in the cytoplasm - activation of NF-kappa B with translocation to the nucleus appears to require phosphorylation-dependent proteolysis of IkB Structure: - IkB proteins contain 5-7 ankyrin repeat domains which interact with Rel regions

Interactions

molecular events

Related

IkB kinase complex nuclear factor kappa-B (NF-kappa B)

Specific

NF-kappa B inhibitor alpha; IKB-alpha; MHC enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; NFKBIA; IKBA (MAD3, NFKBI) NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkappaBbeta; IkB-beta; IkB-B; thyroid receptor-interacting protein 9; TRIP-9; TR-interacting protein 9 (NFKBIB, IKBB, TRIP9) NF-kappaB inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkappaBepsilon; IkB-epsilon; IkB-E (NFKBIE, IKBE)

General

ankyrin repeat domain protein (ANKRD) phosphoprotein

Figures/Diagrams

TNFR/IL1R1/CD28/TCR-CD3 -> NF kappa B

Properties

COMPARTMENT: cytoplasm MOTIF: S/T phosphorylation site ankyrin repeat NAME: ankyrin repeat

References

  1. Thompson CC, Brown TA, McKnight SL. Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex. Science. 1991 Aug 16;253(5021):762-8. PMID: 1876833
  2. Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science. 1995 Mar 10;267(5203):1485-8. PMID: 7878466
  3. Baeuerle PA, Baltimore D. NF-kappa B: ten years after. Cell. 1996 Oct 4;87(1):13-20. No abstract available. PMID: 8858144

Component-of

molecular complex