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hypoxia inducible factor
Function:
- trancription factors that bind to the hypoxia response elements (HREs) of target promoters in hypoxia
- regulation of erythropoietin production by the liver & kidneys
- regulated by oxygen-dependent proteasomal degradation, with a family of prolyl hydroxylases (HIF-prolyl hydroxylases) serving as oxygen sensors
Related
hypoxia-inducible factor prolyl hydroxylase; Egl nine homolog; HIF-prolyl hydroxylase (EGLN)
hypoxia-inducible gene 2 protein (HIG2, HILPDA, C7orf68)
Specific
hypoxia inducible factor 1
hypoxia inducible factor 2
hypoxia-inducible factor 3 alpha (HIF-3 alpha, HIF3 alpha 1, member of PAS protein 7, basic-helix-loop-helix-PAS protein MOP7, inhibitory PAS domain protein, IPAS, HIF3A, MOP7)
General
transcription factor (TF)
Properties
COMPARTMENT: cell nucleus
References
- Chertow GM, Pergola PE, Farag YMK
Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD.
N Engl J Med 2021; 384:1589-1600. April 29
PMID: 33913637
https://www.nejm.org/doi/full/10.1056/NEJMoa2035938