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hypothalamic disease
Etiology:
- malnutrition
- anorexia
- bulimia
- genetic diseases
- radiation
- surgery
- head trauma
- intracranial lesion
- brain tumor
- craniopharyngioma
- infiltrative disease
- sarcoidosis
- Langerhans cell histiocytosis
- lymphoma [3]
- metastatic cancer
- lung cancer
- breast cancer
- aging ?
Pathology:
- secondary hypopituitarism
- central diabetes insipidus
- tertiary hypothyroidism
- developmental disorders
Clinical manifestations:
- disruption in body temperature regulation
- growth retardation
- excess eating (hyperphagia) & weight gain, morbid obesity
- electrolyte imbalance (Na+ & water balance)
- emotional lability
- hypersexuality
- somnolence
- sleep cycle disorder
Related
hypothalamus
Specific
central diabetes insipidus; diabetes insipidus, neurohypophyseal type (CDI)
overtraining syndrome
General
neuroendocrine disease
References
- Wikipedia: Hypothalamic disease
http://en.wikipedia.org/wiki/Hypothalamic_disease
- Martin JB, Riskind PN.
Neurologic manifestations of hypothalamic disease.
Prog Brain Res. 1992;93:31-40; discussion 40-2.
PMID: 1480755
- Medical Knowledge Self Assessment Program (MKSAP) 16,
American College of Physicians, Philadelphia 2012