hyposplenism

(also see splenectomy) Etiology: 1) congenital hyposplenism (Fanconi's syndrome) 2) surgical splenectomy 3) hyposplenism of old age 4) splenic congestion a) hemoglobinopathy -> sickle cell disease b) myeloproliferative disorder 1] essential thrombocytosis 2] myelofibrosis 5) impaired vascular supply to the spleen 6) immunological or autoimmune disorders a) systemic lupus erythematosus b) rheumatoid arthritis c) systemic necrotizing vasculitis d) sarcoidosis e) graft versus host disease following bone marrow transplantation f) IgA deficiency g) thyroiditis h) thyrotoxicosis 7) gastrointestinal disease a) celiac disease b) dermatitis herpetiformis c) ulcerative colitis d) regional enteritis e) intestinal lymphangiectasia f) chronic active hepatitis 8) malignancies a) Sezary syndrome b) multiple myeloma c) gastric carcinoma d) breast carcinoma e) primary splenic angiosarcoma f) non-Hodgkin's lymphoma g) mastocytosis 9) splenic irradiation 10) drug induced a) Thorotrast therapy b) IV immunoglobulin c) alpha-methyldopa d) glucocorticoids 11) systemic amyloidosis 12) nephrotic syndrome 13) splenic trauma 14) disseminated Varicella

Related

spleen splenectomy

References

Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 328