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hypoplastic anemia
Also see aplastic anemia
Etiology:
1) iron deficiency
2) anemia of chronic disease
a) inflammation
b) renal disease
c) liver disease
d) endocrine failure
4) hypometabolic states
5) stem cell disorder
- hemoglobinopathy
6) inhibitors of heme synthesis
a) lead intoxication
b) isoniazid, pyrazinamide
7) sideroblastic anemia
8) leukemia
Laboratory:
1) erythropoietin in serum
2) CBC with reticulocyte count
3) bone marrow biopsy
4) see anemia & aplastic anemia
Management:
1) Epogen or other erythropoietin may be helpful
- may diminish survival when used to treat malignancy- related anemia [4]
- target Hgb > 12 g/dL may diminish survival [3]
2) see aplastic anemia
Interactions
disease interactions
Related
microcytic anemia
Specific
anemia of chronic disease (ACD)
aplastic anemia
iron-deficiency anemia
myelophthisic anemia
sideroblastic anemia
General
anemia
bone marrow hypoplasia/failure (myelosuppression)
References
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 643
- Schiller G, UCLA Intensive Course in Geriatric Medicine &
Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- Prescriber's Letter 14(1): 2007
Erythropoiesis Stimulating Agents (Aranesp, Epogen, and Procrit):
Caution not to Exceed Recommended Hemoglobin Targets
Detail-Document#: 230105
(subscription needed) http://www.prescribersletter.com
- Wright JR et al,
Randomized, double-blind, placebo-controlled trial of
erythropoietin in non-small cell lung cancer with disease-
related anemia.
J Clin Oncol 2007, 25:1021
PMID: 17312332