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hypoalphalipoproteinemia
Etiology:
1) primary hypoalphalipoproteinemia
2) secondary causes of diminished HDL:
a) type 2 diabetes mellitus
b) impaired glucose tolerance
c) insulin-resistance
d) obesity
e) androgen excess in females
f) renal failure
g) pharmaceutical agents
1] retinoids
2] beta-blockers
3] anabolic steroids*
* selective reduction in HDL; other causes of diminished HDL also elevate serum triglycerides
Management:
- nicotinic acid (niacin) is the drug of choice
Specific
familial HDL deficiency (familial hypoalphalipoproteinemia)
General
hypolipoproteinemia
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Singh VN and Griffing GT
eMedicine: Low HDL Cholesterol (Hypoalphalipoproteinemia)
http://emedicine.medscape.com/article/127943-overview