Search
hypertrichosis
Etiology:
1) pharmacologic
a) phenytoin
b) minoxidil
c) cyclosporine (80%)
d) penicillamine
e) phenothiazines
f) acetazolamide
g) psoralens
h) diazoxide (50%)
i) Streptomycin
j) oral corticosteroids
k) hexachlorobenzene [4]
l) methyldopa
m) metaclopramide
n) reserpine [4]
2) genetic
a) Edward's syndrome (trisomy 18)
b) Hurler's syndrome
c) Cornelia de Lange syndrome
d) congenital hypertrichosis
e) Seckel's dwarfism
f) Turner's syndrome (gonadal dysgenesis)
3) metabolic
a) anorexia nervosa
b) hypertrichosis lanuginosa acquisita
c) hyperthyroidism [4]
d) juvenile hypothyroidism
e) porphyria
f) acromegaly
Pathology:
- androgen-independent increase in vellus & terminal hair growth
Clinical manifestations:
- increase in vellus & terminal hair growth
* images [5]
Laboratory:
- 24 hour urine porphyrins
- porphyrin in stool
- thyroid function testing
Special laboratory:
- colonoscopy if hypertrichosis lanuginosa suspected
Related
hirsutism
Specific
Cantu syndrome; hypertrichotic osteochondrodysplasia
hypertrichosis lanuginosa acquisita
General
hairiness
References
- Saunders Manual of Medical Practice, Rakel (ed),
WB Saunders, Philadelphia, 1996, pg 619
- DeGowin & DeGowin's Diagnostic Examination, 6th edition,
RL DeGowin (ed), McGraw Hill, NY 1994, pg 861
- Color Atlas & Synopsis of Clinical Dermatology, Common
& Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY,
1997, pg 46-47
- Medical Knowledge Self Assessment Program (MKSAP) 17, 18.
American College of Physicians, Philadelphia 2015, 2018.
- DermNet NZ. Hypertrichosis (images)
http://dermnetnz.org/hair-nails-sweat/hypertrichosis.html