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3% saline
Indications:
- treatment of symptomatic hyponatremia
Dosage:
- 513 meq Na+/L
- infusion to increase serum sodium < 0.5 meq/L/hour &
a) < 10 meq/L/24 hours, < 18 meq/L/48 hrs
b) target: 4-6 meq/24 hours
c) central pontine myelinolysis is danger of too rapidly correcting sodium
d) serum Na+ is usually corrected to 120 meq/L
Adverse effects:
- D5W +/- desmopressin for overcorrection of hyponatremia
- IV furosemide (Lasix) may be given for volume overload
General
saline
References
- Medical Knowledge Self Assessment Program (MKSAP) 16, 18
American College of Physicians, Philadelphia 2012, 2018