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hypersegmented neutrophil count

Indications: - evaluation of megaloblastic anemia Normal range: - not normally present Clinical significance: - seen in association with megaloblastic anemia - aged, degenerated neutrophils with excessive nuclear segmentation - 5 or more lobes define a hypersegmented neutrophil - typically neutrophils have 2-4 lobes - up to 5% of neutrophils in patients with megaloblastic anemia are hypersegmented - in nutritional megaloblastic anemia, a) hypersegmented neutrophils are an early sign b) correction of the nutritional deficit generally clears hypersegmented neutrophils from the blood stream in 2 days; however, it may take months Specimen: - Whole blood (EDTA) - Stable for 24 h at 4 C

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hypersegmented neutrophil count

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segmented neutrophil count

References

  1. Williams Hematology, 5th ed, Beutler et al (eds), McGraw Hill, NY, 1995, pg 472
  2. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
  3. Panel of 38 tests Laboratory Test Directory ARUP: 40005

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