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hyperbaric oxygen

Oxygen at greater than atmospheric pressure that can be applied either to the whole patient inside a pressurized chamber or to a localized area (such as an arm or leg) inside a smaller chamber. Indications: - poisonings, drug overdose (potentially of benefit) a) carbon monoxide b) cyanide poisoning c) hydrogen sulfide d) brown recluse spider bite e) acetaminophen poisoning f) non healing diabetic foot ulcer (covered by Medicare) [2] - hyperbaric oxygen decreases amputation rates [3] - does not decrease need for amputation [6] Contraindications: - untreated pneumothorax [3] - recent chemotherapy with doxorubicin or cisplatin [3] - caution: - heart failure - COPD - other concurrent antineoplastic agent(s) - has not been proven effective for treating - AIDS/HIV1 - Alzheimer's disease [7] - asthma - Bell's palsy - brain injury - cerebral palsy - depression - heart disease - hepatitis - migraine - multiple sclerosis - Parkinson's disease - spinal cord injury - sport's injury - stroke Procedure: diabetic foot ulcer - treatment applied in chamber for 1.5-2 hours/day for 20-40 days Adverse effects: - sinus pain - ear pressure - arthralgia - air embolism - paralysis - risk of fire

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hyperbaric oxygen therapy

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aerotherapy oxygen therapy

References

  1. Daubert GP, Emergency Medicine, University of California, Davis
  2. Geriatrics at your Fingertips, 13th edition, 2011 Reuben DB et al (eds) American Geriatric Society
  3. Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012
  4. Eskes A, Ubbink DT, Lubbers M, Lucas C, Vermeulen H. Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD008059 PMID: 20927771
  5. FDA Consumer Update. August 22, 2013 Hyperbaric Oxygen Therapy: Don't Be Misled http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm364687.htm
  6. Fedorko L et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: A prospective, double-blind, randomized controlled clinical trial. Diabetes Care 2016 Mar; 39:392. PMID: 26740639
  7. Shapira R, Efrati S, Ashery U. Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease. Neural Regen Res. 2018 May;13(5):817-818. PMID: 29863011 Free PMC article. No abstract available. - Shapira R, Gdalyahu A, Gottfried I et al Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer's disease mouse model and in elderly patients. Aging (Albany NY). 2021 Sep 9;13(17):20935-20961. Epub 2021 Sep 9. PMID: 34499614 Free PMC article.