hyper-IgM immunodeficiency syndrome (HIGM)

Pathology: - absence of Ig class switch recombination Clinical manifestations: - profound susceptibility to bacterial infections Laboratory: - normal or elevated serum IgM levels - absence of serum IgG, serum IgA, & serum IgE

Specific

hyper-IgM immunodeficiency syndrome type 2 (HIGM2) hyper-IgM immunodeficiency syndrome type 3 (HIGM3) hyper-IgM immunodeficiency syndrome type 5 (HIGM5) hyper-IgM immunodeficiency syndrome type1; X-linked hyper IgM syndrome (HIGM1)

General

humoral immune dysfunction syndrome

References

OMIM :accession 605258, 608106