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HVET study
Study characteristics:
- 80+ years of age, mean age 84 years
- 3845 patients from Europe, China, Australasia, & Tunisia
- randomized study, placebo-controlled
- mean blood pressure 173/91 mm Hg
Treatment:
- treatment with indapamide SA 1.5 mg or placebo + perindopril 2-4 mg or placebo as necessary to achieve BP of 150/80
Results:
- BP lower in treatment group, mean 15/6 mm Hg
- allegedly, mean BP achieved in treatment group 143/78 [2]
- 30% reduction in mortality from stroke in treated group (p=0.046) 12.4 vs 17.7 per 1000 patient years
- number need to treat to prevent 1 stroke in 2 years = 100
- 21% reduction in all-cause mortality (p=0.02) (10% vs 12%)
- 64% reduction in heart failure
- fewer adverse effects in the treatment group (358 vs 448)
- another account says only 2 serious adverse events, both in the indapamide group
- trial halted early because of ethical concerns
- sponsored by manufacturer of study drugs
References
- Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L et al;
the HYVET Study Group.
Treatment of Hypertension in Patients 80 Years of Age or Older.
N Engl J Med. 2008 Mar 31; [Epub ahead of print]
PMID: 18378519
- Kostis JB
Treating hypertension in the very old
N Engl J Med 2008, March 31
PMID: 18378522
- UpToDate, version 17.1