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tumor necrosis factor receptor superfamily member 14; Herpesvirus entry mediator A; tumor necrosis factor receptor-like 2; TR2 (TNFRSF14, HVEA, HVEM, UNQ329/PRO509)
Function:
- receptor for BTLA
- receptor for
a) TNFSF14/LIGHT
b) homotrimeric TNFSF1/lymphotoxin-alpha
- role in lymphocyte activation
- interacts with TRAF2, TRAF3 & TRAF5
Structure:
- N-glycosylated
- contains 3 TNFR-Cys repeats
Compartment: membrane
Expression:
- widely expressed
- highest expression in lung, spleen & thymus
Pathology:
- role in HSV pathogenesis
- enhances entry of several wild-type HSV strains of both serotypes into CHO cells
- mediates HSV entry into activated human T-cells
Interactions
molecular events
General
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 283 aa
MW = 30 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-38}
TNFR-Cys {42-75}
MOTIF: cysteine residue {C42}
MODIFICATION: cysteine residue {C53}
cysteine residue {C53}
MODIFICATION: cysteine residue {C42}
cysteine residue {C54}
MODIFICATION: cysteine residue {C67}
cysteine residue {C57}
MODIFICATION: cysteine residue {C75}
cysteine residue {C67}
MODIFICATION: cysteine residue {C54}
cysteine residue {C75}
MODIFICATION: cysteine residue {C57}
TNFR-Cys {78-119}
MOTIF: cysteine residue {C78}
MODIFICATION: cysteine residue {C93}
cysteine residue {C93}
MODIFICATION: cysteine residue {C78}
cysteine residue {C96}
MODIFICATION: cysteine residue {C111}
cysteine residue {C99}
MODIFICATION: cysteine residue {C119}
N-glycosylation site {N110}
cysteine residue {C111}
MODIFICATION: cysteine residue {C96}
cysteine residue {C119}
MODIFICATION: cysteine residue {C99}
TNFR-Cys {121-162}
MOTIF: cysteine residue {C121}
MODIFICATION: cysteine residue {C138}
cysteine residue {C127}
MODIFICATION: cysteine residue {C135}
cysteine residue {C135}
MODIFICATION: cysteine residue {C127}
cysteine residue {C138}
MODIFICATION: cysteine residue {C121}
N-glycosylation site {N173}
transmembrane domain {203-223}
Database Correlations
OMIM 602746
UniProt Q92956
Pfam PF00020
Entrez Gene 8764
Kegg hsa:8764
References
- UniProt :accession Q92956
- NIEHS-SNPs
http://egp.gs.washington.edu/data/tnfrsf14/