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guanine nucleotide-binding protein-like 1; GTP-binding protein HSR1 (GNL1, HSR1)
Function:
- possible regulatory or functional link with the histocompatibility cluster
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- in contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern
- belongs to the MMR1/HSR1 GTP-binding protein family
Alternative splicing: named isoforms=2
General
guanine nucleotide regulatory protein (GNRP)
phosphoprotein
Properties
SIZE: entity length = 607 aa
MW = 69 kD
MOTIF: Ser phosphorylation site {S32}
Ser phosphorylation site {S33}
Ser phosphorylation site {S34}
Thr phosphorylation site {T48}
Thr phosphorylation site {T50}
Ser phosphorylation site {S51}
Ser phosphorylation site {S68}
GTP-binding site
SITE: 225-228
Ser phosphorylation site {S324}
GTP-binding site
SITE: 367-374
GTP-binding site
SITE: 411-415
acidic region {551-607}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S561}
Ser phosphorylation site {S562}
Ser phosphorylation site {S563}
Database Correlations
OMIM 143024
UniProt P36915
Pfam PF01926
Entrez Gene 2794
Kegg hsa:2794
References
UniProt :accession P36915