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heat shock protein 105 kD; heat shock 110 kD protein; antigen NY-CO-25 (HSPH1, HSP105, HSP110, KIAA0201)
Function:
- prevents aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly
- inhibits HSPA8/HSC70 ATPase & chaperone activities
- phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity (putative)
- interacts with HSPA8/HSC70 (putative)
Structure: belongs to the heat shock protein 70 family
Compartment: cytoplasm
Alternative splicing: named isoforms=3; alpha, beta
Expression:
- highly expressed in testis
- low expression in most brain regions
- not expressed in cerebellum
Pathology:
- overexpressed in cancer cells
General
heat shock protein
phosphoprotein
Properties
SIZE: entity length = 858 aa
MW = 97 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S31}
Ser phosphorylation site {S384}
Ser phosphorylation site {S509}
Ser phosphorylation site {S557}
Ser phosphorylation site {S562}
Thr phosphorylation site {T700}
Ser phosphorylation site {S809}
Thr phosphorylation site {T815}
Database Correlations
OMIM 610703
UniProt Q92598
Pfam PF00012
Entrez Gene 10808
Kegg hsa:10808
References
- UniProt :accession Q92598
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/HSPH1ID40891ch13q12.html