Search
heat shock protein HSP 90-alpha; HSP 86; renal carcinoma antigen NY-REN-38 (HSP90AA1, HSP90A, HSPC1, HSPCA)
Function:
- molecular chaperone
- ATPase activity
- interacts with AHSA1, SMYD3 & TOM34
- interacts with FNIP1 & HSF1
Structure:
- homodimer
- belongs to the heat shock protein 90 family
Compartment:
- cytoplasm, melanosome
- identified by mass spectrometry in melanosome fractions from stage 1 to stage 4
Alternative splicing: named isoforms=2
Specific
heat shock protein HSP 90-alpha A2 (heat shock 90 kD protein 1 alpha-like 3, HSP90AA2, HSPCAL3)
General
heat shock protein [hsp]-90
Properties
SIZE: entity length = 732 aa
MW = 85 kD
COMPARTMENT: cytoplasm
MOTIF: Thr phosphorylation site {T5}
Thr phosphorylation site {T7}
Ser phosphorylation site {S231}
Ser phosphorylation site {S252}
Ser phosphorylation site {S263}
Tyr phosphorylation site {Y313}
Tyr phosphorylation site {Y492}
Database Correlations
OMIM 140571
UniProt P07900
PFAM correlations
Entrez Gene 3320
References
- UniProt :accession P07900
- Martinus RD et al
Role of chaperones in the biogenesis and maintenance of the
mitochondrion.
FASEB J. 1995 Mar;9(5):371-8. Review.
PMID: 7896006