Hsp70-binding protein 1 (HspBP1, heat shock protein-binding protein 1, Hsp70-interacting protein 1, Hsp70-binding protein 2, HspBP2, Hsp70-interacting protein 2, HSPBP1, HSPBP, PP1845)

Function: - inhibits HSPA1A chaperone activity by changing conformation of the ATP-binding domain of HSPA1A & interfering with ATP binding - interferes with ubiquitination mediated by STUB1 & inhibits chaperone-assisted degradation of immature CFTR - interacts with the ATP-binding domain of HSPA1A - detected in a ternary complex containing STUB1, HSPA1A & HSPBP Structure: contains 4 ARM repeats Alternative splicing: named isoforms=2 Expression: ubiquitous

Properties

SIZE: MW = 39 kD entity length = 362 aa MOTIF: glycine-rich region {21-40} ARM repeat {135-177} ARM repeat {180-220} ARM repeat {223-262} ARM repeat {265-304}

References

UniProt :accession Q9NZL4