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HSPB1-associated protein 1 (27 kD heat shock protein-associated protein 1, protein associated with small stress protein 1, HSPBAP1, PASS1)
Function:
1) role in cellular stress response
2) interacts with CRYAB & HSPB
Structure: contains 1 JmjC domain
Compartment: cytoplasm
Alternative splicing: named isoforms=3
Expression: widely expressed Patholology:
- chromosomal translocation t(2;3)(q35;q21) involving HSPBAP1 with the putative pseudogene DIRC3 is found in familial renal cell carcinoma 1
- results in hybrid mRNA encoding a truncated HSPBAP1 lacking 1st 36 amino acids
General
other protein
Properties
SIZE: MW = 55 kD
entity length = 488 aa
COMPARTMENT: cytoplasm
MOTIF: HSPB1 interaction {88-208}
JmjC {124-288}
Database Correlations
OMIM correlations
UniProt Q96EW2
Pfam PF02373
References
- UniProt :accession Q96EW2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/HSPBAP1ID513.html