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heat shock protein beta-1; HspB1; heat shock 27 kD protein; HSP 27; stress-responsive protein 27; SRP27; estrogen-regulated 24 kD protein; 28 kD heat shock protein (HSPB1, HSP27, HSP28)
A member of the hsp20 or low molecular weight hsp family.
Function:
- role in stress resistance & actin organization
- phosphorylated in MCF-7 cells on exposure to
a) protein kinase C activators
b) heat shock
- interacts with TGFB1I1 (putative)
- interacts with hspB8, HSPBAP1, CRYAB
- associates with:
a) alpha-tubulin
b) beta-tubulin
c) microtubules
- induced by
a) heat shock
b) estrogen stimulation
Structure:
- belongs to the small heat shock protein (HSP20) family
Compartment:
- cytoplasm, nucleus, spindle
- cytoplasmic in interphase cells
- colocalizes with mitotic spindles in mitotic cells
- translocates to the nucleus during heat shock
Expression:
- detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood (serum) & cerebrospinal fluid
- highest levels are found in the heart & in tissues composed of striated & smooth muscle
- expressed in response to environmental stresses such as heat shock, or estrogen stimulation in MCF-7 cells
Pathology:
- mutations associated with:
a) Charcot-Marie-Tooth disease type 2F (CMT2F)
b) distal hereditary motor neuropathy (dHMN)
Interactions
molecular events
General
heat shock protein [hsp]-20 family or small heat shock protein family
phosphoprotein
Properties
SIZE: entity length = 205 aa
MW = 23 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S15}
Ser phosphorylation site {S26}
Ser phosphorylation site {S65}
TGFB1I1 interaction {70-205}
MOTIF: Ser phosphorylation site {S78}
Ser phosphorylation site {S82}
Ser phosphorylation site {S83}
Ser phosphorylation site {S199}
Database Correlations
OMIM correlations
MORBIDMAP 602195
UniProt P04792
Pfam PF00011
Entrez Gene 3315
Kegg hsa:3315
References
- Martinus RD
Role of chaperones in the biogenesis and maintenance of
the mitochondrion.
FASEB J 9:371 1995
PMID: 7896006
- Prosite :accession PS01031
- UniProt :accession P04792
- Inherited peripheral neuropathies mutation db
http://www.molgen.ua.ac.be/CMTmutations/
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=HSPB1
- NIEHS SNPs
http://egp.gs.washington.edu/data/hspb1/