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heat shock cognate 71 kD protein (heat shock 70 kD protein 8, HSPA8, HSC70, HSP73, HSPA10)
Function:
- chaperone
- isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the cochaperones
- interacts with HSPH1/HSP105 (putative)
- interacts with PACRG & TSC2
- phosphorylated upon DNA damage, probably by ATM or ATR
- uncoating enzyme, drives disassembly of clathrin coat [1,2]?
Structure: belongs to the heat shock protein 70 family
Compartment:
- cytoplasm, melanosome
- translocates rapidly from cytoplasm to nuclei, & especially to the nucleoli, upon heat shock
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- constitutively synthesized
General
chaperonin; chaperone
heat shock protein [hsp]-70 family
phosphoprotein
Properties
SIZE: entity length = 646 aa
MW = 71 kD
COMPARTMENT: cytoplasm
MOTIF: Tyr phosphorylation site {Y15}
Ser phosphorylation site {S153}
Thr phosphorylation site {T477}
MISC-INFO: P-ISOELECTRIC 5.5-5.8
Database Correlations
OMIM 600816
UniProt P11142
Pfam PF00012
References
- Arlan Richardson, AGE meeting Oct 3-6,
1990 New York, NY
- Martinus RD et al
Role of chaperones in the biogenesis and maintenance of the
mitochondrion.
FASEB J. 1995 Mar;9(5):371-8. Review.
PMID: 7896006
- UniProt :accession P11142
Component-of
histone H3-specific methyltransferase complex