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heat shock 70 kD protein 1A; heat shock 70 kD protein 1; HSP70-1; HSP70.1 (HSPA1A, HSPA1, HSX70, HSP1A)

Function: - in cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation & mediate folding of newly translated polypeptides in the cytosol as well as within organelles - Hsp70s precognize nonnative conformations of other proteins - they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation & membrane translocation, or following stress-induced damage - in the case of rotavirus A infection, HSPA1A serves as a post- attachment receptor for the virus to facilitate entry into the cell - essential for STUB1-mediated ubiquitination & degradation of FOXP3 in regulatory T-cells (treg) during inflammation - component of the catsper complex - identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs - interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C & TSC2 - interacts with TERT - interaction occurs in the absence of the RNA component, TERC, & dissociates once the TERT complex has formed - interacts with TRIM5 (via B30.2/SPRY domain) - interacts with METTL21A - interacts with DNAAF2 (putative) - interacts with PARK2 - interacts with FOXP3 - interacts with NOD2 - interaction enhances NOD2 stability - interacts with DNAJC9 (via J domain) - interacts with ATF5 - interaction protects ATF5 from degradation via proteasome-dependent & caspase-dependent processes Structure: - belongs to the heat shock protein 70 family Compartment: - cytoplasm - localized in cytoplasmic mRNP granules containing untranslated mRNAs Alternative splicing: named isoforms=2 Expression: induced by heat shock

General

heat shock protein phosphoprotein

Properties

SIZE: entity length = 641 aa MW = 70 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl ATP-binding site NAME: ATP-binding site SITE: 12-15 ATP-binding site NAME: ATP-binding site SITE: 71-71 ATP-binding site NAME: ATP-binding site SITE: 202-204 ATP-binding site NAME: ATP-binding site SITE: 268-275 ATP-binding site NAME: ATP-binding site SITE: 339-342 Ser phosphorylation site {S631} Ser phosphorylation site {S633} Thr phosphorylation site {T636}

Database Correlations

OMIM correlations UniProt P0DMV8 Pfam PF00012 LOCUS-LINK correlations KEGG correlations

References

  1. UniProt :accession P0DMV8
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/hspa1a/

Component-of

mRNP granule complex