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DnaJ homolog subfamily B member 1; heat shock 40 kD protein 1; heat shock protein 40; HSP40; DnaJ protein homolog 1; HDJ-1; zouotin; CbpA; Sis1p; Caj1; Scj1p; Ydj1p; Mas5P (DNAJB1, DNAJ1, HDJ1, HSPF1)
Function:
- interacts with HSP70 & can stimulate its ATPase activity
- stimulates association between HSC70 & HIP
- interacts with DNAJC3
Structure: contains 1 J domain
Compartment:
- cytoplasm, nucleus, nucleolus
- translocates rapidly from the cytoplasm to the nucleus, & especially to the nucleoli, upon heat shock
Expression: induced by heat shock
General
DNAJ homolog subfamily B
heat shock protein
Properties
SIZE: MW = 40 kD
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: J domain {1-70}
Database Correlations
OMIM 604572
UniProt P25685
PFAM correlations
Entrez Gene 3337
Kegg hsa:3337
References
- UniProt :accession P25685
- Martinus RD et al
Role of chaperones in the biogenesis and maintenance of the
mitochondrion.
FASEB J 9:371 1995
PMID: 7896006
- Prosite :accession PS00636
- Prosite :accession PS00637