17-beta-hydroxysteroid dehydrogenase 12 (estradiol 17-beta-dehydrogenase 12, 17-beta-HSD 12, 3-ketoacyl-CoA reductase, KAR, HSD17B12)

Function: 1) biosynthesis of estrogens 2) fatty acid biosynthesis 3) catalyzes the transformation of estrone to estradiol (major enzyme responsible for this conversion in women) 4) 3-ketoacyl-CoA reductase activity a) reduces both long chain 3-ketoacyl-CoAs & long chain fatty acyl-CoA b) long fatty acid elongation Compartment: endoplasmic reticulum membrane Expression: - expressed in most tissues - highly expressed in the ovary, breast, expressed in platelets

General

17 beta-hydroxysteroid dehydrogenase (estradiol 17 beta-dehydrogenase, HSD17B1) membrane protein

Properties

SIZE: MW = 34 kD entity length = 312 aa COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {4-24} cofactor-binding site [50-79] COFACTOR-BOUND: NAD transmembrane domain {182-202} MOTIF: binding site SITE: 189-189 FOR-BINDING-OF: estrone tyrosine residue {Y202} transmembrane domain {271-291}

Database Correlations

UniProt Q53GQ0 Pfam PF00106 ENZYME correlations

References

UniProt :accession Q53GQ0