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11-beta hydroxysteroid dehydrogenase-2 (corticosteroid 11-beta-dehydrogenase isozyme 2, 11-DH2, 11-beta-hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, HSD11B2 HSD11K)
Function:
- catalyzes conversion of cortisol to inactive metabolite cortisone
- modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids
- interacts with ligand-free cytoplasmic NR3C2
11-beta-hydroxysteroid + NAD+ 11- oxosteroid + NADH
Inhibition:
- inhibited by glycyrrhetinic acid (derived from liquorice), carbenoloxone & 11-alpha-OH-progesterone
Structure:
- belongs to the short-chain dehydrogenases/reductases (SDR) family
Compartment: microsome
Expression:
- found in placenta, kidney, pancreas, prostate, ovary, small intestine & colon
Pathology:
- defects in HSD11B2 are the cause of apparent mineralocorticoid excess
General
11-OH steroid dehydrogenase; corticosteroid 11-beta dehydrogenase
Properties
SIZE: entity length = 405 aa
MW = 44 kD
MOTIF: binding site
SITE: 219-219
FOR-BINDING-OF: Substrate
tyrosine residue {Y232}
Database Correlations
OMIM 218030
UniProt P80365
Pfam PF00106
ENZYME 1.1.1.146
References
- UniProt :accession P80365
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=HSD11B