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heparan sulfate glucosamine 3-O-sulfotransferase 3B1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1; 3-OST-3B; heparan sulfate 3-O-sulfotransferase 3B1; h3-OST-3B (HS3ST3B1, 3OST3B1, HS3ST3B)
Function:
- transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate
- catalyzes O-sulfation of glucosamine in IdoUA2S-GlcNS & also in IdoUA2S-GlcNH2
- unlike HS3ST1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
Structure: belongs to the sulfotransferase 1 family
Compartment:
- Golgi membrane
- single-pass type 2 membrane protein (probable)
Expression:
- ubiquitous
- expressed in liver & placenta > heart & kidney
Pathology:
- substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) & permits its entry
Related
glucosamine (Cosamin, Osteo-Bi-Flex)
heparan sulfate
General
heparan sulfate glucosamine 3-O-sulfotransferase (HS3ST)
human longevity protein
membrane protein
Properties
SIZE: entity length = 390 aa
MW = 43 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {33-53}
Substrate binding {169-175}
Substrate binding {200-203}
binding site
SITE: 228-228
FOR-BINDING-OF: 3'-phosphoadenosine-5'-phosphosulfate
binding site
SITE: 236-236
FOR-BINDING-OF: 3'-phosphoadenosine-5'-phosphosulfate
N-glycosylation site {N258}
Substrate binding {268-269}
N-glycosylation site {N329}
cysteine residue {C336}
MODIFICATION: cysteine residue {C348}
cysteine residue {C348}
MODIFICATION: cysteine residue {C336}
Database Correlations
OMIM 604058
UniProt Q9Y662
Pfam PF00685
Entrez Gene 9953
Kegg hsa:9953
ENZYME 2.8.2.30
References
- UniProt :accession Q9Y662
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/