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heparan sulfate glucosamine 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; h3-OST-3A (HS3ST3A1, 3OST3A1, HS3ST3A, UNQ2551/PRO6180)
Function:
- transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate
- catalyzes O-sulfation of glucosamine in IdoUA2S-GlcNS & also in IdoUA2S-GlcNH2
- unlike HS3ST1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
Structure: belongs to the sulfotransferase 1 family
Compartment:
- Golgi membrane
- single-pass type 2 membrane protein (probable)
Expression:
- ubiquitous
- expressed in heart & placenta > liver & kidney
Pathology:
- the substrate-specific O-sulfation generates an enzyme- modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) & permits its entry.
Related
glucosamine (Cosamin, Osteo-Bi-Flex)
heparan sulfate
General
heparan sulfate glucosamine 3-O-sulfotransferase (HS3ST)
membrane protein
Properties
SIZE: entity length = 406 aa
MW = 45 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {25-43}
Substrate binding {184-190}
Substrate binding {215-218}
N-glycosylation site {N273}
Substrate binding {283-284}
N-glycosylation site {N344}
cysteine residue {C351}
MODIFICATION: cysteine residue {C363}
cysteine residue {C363}
MODIFICATION: cysteine residue {C351}
Database Correlations
OMIM 604057
UniProt Q9Y663
Pfam PF00685
Entrez Gene 9955
Kegg hsa:9955
ENZYME 2.8.2.30
References
- UniProt :accession Q9Y663
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/