HRAS-like suppressor 3; H-rev 107 protein homolog; HREV107-3; renal carcinoma antigen NY-REN-65 (HRASLS3, HREV107, PLA2G16)

Function: - tumor suppressor - role in interferon-dependent cell death Structure: - belongs to the H-rev107 family Expression: - ubiquitously expressed, except in haematopoetic cells - found in normal ovarian epithelial cells Pathology: - consistently down-regulated in tumorigenic human cell lines - down-regulated in ovarian carcinomas

General

anti-oncoprotein (tumor suppressor protein) H-rev107 family membrane protein

Properties

SIZE: MW = 18 kD entity length = 162 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {134-154}

Database Correlations

UniProt P53816 Pfam PF04970

References

UniProt :accession P53816