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neutrophil defensin 1; defensin, alpha 1; HNP-1; HP-1; HP1; contains: neutrophil defensin 2 (DEFA1, DEF1, MRS, DEFA1B)
Function:
- defensin 1 & defensin 2 have antibacterial, fungicide & antiviral activities
- defensin 2 apparently arises from cleavage of defensin 1 or defensin 3
- antimicrobial activity against Gram-negative & Gram-positive bacteria
- defensins are thought to kill microbes by permeabilizing their plasma membrane
- ADP-ribosylation drastically reduces cytotoxic & antibacterial activities, & enhances IL8 production
- phosphorylation at Tyr-85 has been found in some cancer cell lines, & interferes with ADP-rybosylation
Structure:
- dimer
- belongs to the alpha-defensin family
Compartment:
- found in microbicidal granules of neutrophils
- secreted
General
defensin
phosphoprotein
Properties
SIZE: entity length = 94 aa
MW = 10 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
cysteine residue {C66}
MODIFICATION: cysteine residue {C94}
cysteine residue {C68}
MODIFICATION: cysteine residue {C83}
cysteine residue {C73}
MODIFICATION: cysteine residue {C93}
cysteine residue {C83}
MODIFICATION: cysteine residue {C68}
Tyr phosphorylation site {Y85}
cysteine residue {C93}
MODIFICATION: cysteine residue {C73}
cysteine residue {C94}
MODIFICATION: cysteine residue {C66}
Database Correlations
OMIM 125220
UniProt P59665
PFAM correlations
LOCUS-LINK correlations
KEGG correlations
References
- UniProt :accession P59665
- OMIM :accession 125220