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homeobox protein HOX-A9; Hox-1G (HOXA9, HOX1G)
Function:
- sequence-specific transcription factor
- part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
Structure:
- belongs to the Abd-B homeobox family
- contains 1 homeobox DNA-binding domain
Compartment: nucleus
Pathology:
- chromosomal translocation t(7;11)(p15;p15) involving HOXA9 with NUP98 is found in a form of acute myeloid leukemia
- chromosomal translocation t(7;17)(p15;q23) involving HOXA9 with MSI2 may contribute to disease progression in chronic myeloid leukemia
General
homeobox protein
Properties
SIZE: entity length = 272 aa
MW = 30 kD
COMPARTMENT: cell nucleus
MOTIF: peptide motif {163-164}
homeodomain
SITE: 206-265
Database Correlations
OMIM 142956
UniProt P31269
PFAM correlations
Entrez Gene 3205
Kegg hsa:3205
References
- UniProt :accession P31269
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/HOXA9.html