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hot nodule; toxic thyroid adenoma
thyroid nodule that takes up radioactive iodide
Pathology:
- 'hot nodules' secrete thyroxine
- 'hot nodules' virtually never malignant
Laboratory:
- serum TSH low to undetectable
- serum thyroxine & serum free T4 generally elevated (but may be normal)
Radiology:
- thyroid scintigraphy indicated rather than thyroid ultrasound
- thyroid nodule takes up radioactive iodide
Management:
1) radioactive I-131 ablation
2) subtotal thyroidectomy
Related
cold nodule
toxic multinodular goiter (Plummer's disease)
General
thyroid nodule
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 17.
American College of Physicians, Philadelphia 2009, 2015
- Siegel RD, Lee SL
Toxic nodular goiter. Toxic adenoma and toxic multinodular
goiter.
Endocrinol Metab Clin North Am. 1998 Mar;27(1):151-68. Review.
PMID: 9534034