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hormone sensitive lipase (LIPE, HSL)
Function:
- in adipose tissue & heart, primarily hydrolyzes stored triglycerides to free fatty acids
- in steroidogenic tissues, principally converts cholesteryl esters to free cholesterol for steroid hormone production
- interacts with PTRF in the adipocyte cytoplasm
- rapidly activated by catecholamines via cAMP-dependent phosphorylation under the influence of catecholamines
- dephosphorylation & inactivation are controlled by insulin
- glycerolipid degradation, triacylglycerol degradation
diacylglycerol + H2O monoacylglycerol + a carboxylate
triacylglycerol + H2O diacylglycerol + a carboxylate
monoacylglycerol + H2O glycerol + a carboxylate
Structure: belongs to the 'GDXG' lipolytic enzyme family
Compartment:
- cell membrane, caveola
- cytoplasm, cytosol
- found in the high-density caveolae
- translocates to cytoplasm from caveolae upon insulin stimulation
Alternative splicing: named isoforms=2
Interactions
molecular events
General
lipase
phosphoprotein
regulatory molecule
Properties
SIZE: entity length = 1076 aa
MW = 117 kD
COMPARTMENT: cytoplasm
MOTIF: histidine residue {H651}
serine residue {S725}
Ser phosphorylation site {S853}
Ser phosphorylation site {S855}
Ser phosphorylation site {S950}
Ser phosphorylation site {S951}
Database Correlations
OMIM 151750
UniProt Q05469
PFAM correlations
ENZYME 3.1.1.79
References
- OMIM :accession 151750
- UniProt :accession Q05469