heterogeneous nuclear ribonucleoprotein M; hnRNP M (HNRNPM, HNRPM, NAGR1)

Function: - pre-mRNA binding protein in vivo - binds avidly to poly(G) & poly(U) RNA homopolymers in vitro - role in RNA splicing - acts as a receptor for carcinoembryonic antigen in Kupffer cells - may initiate a series of signaling events leading to Tyr phosphorylation of proteins & induction of IL-1 alpha, IL-6, IL-10 & TNF-alpha cytokines - sumoylated - identified in the spliceosome C complex Structure: contains 3 RRM domain (RNA recognition motif)s Compartment: nucleus, nucleolus Alternative splicing: named isoforms=3

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 730 aa MW = 78 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl RNP motif NAME: RNP motif SITE: 71-149 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 204-281 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif glycine-rich region {390-396} 27 X 6 AA repeats of [GEVSTPAN]-[ILMV]- [DE]-[RH]-[MLVI]-[GAV] {400-608} MOTIF: consensus repeat {400-405} consensus repeat {407-412} consensus repeat {415-420} consensus repeat {426-431} Ser phosphorylation site {S432} consensus repeat {433-438} consensus repeat {440-445} consensus repeat {446-451} consensus repeat {453-458} consensus repeat {461-466} consensus repeat {468-473} Ser phosphorylation site {S468} consensus repeat {475-480} consensus repeat {482-487} consensus repeat {493-498} consensus repeat {500-505} consensus repeat {507-512} Ser phosphorylation site {S513} consensus repeat {514-519} consensus repeat {521-526} consensus repeat {528-533} Ser phosphorylation site {S528} consensus repeat {540-545} consensus repeat {547-552} consensus repeat {554-559} consensus repeat {562-567} consensus repeat {567-572} consensus repeat {575-580} consensus repeat {580-585} consensus repeat {588-593} Ser phosphorylation site {S588} consensus repeat {603-608} glycine-rich region {612-616} Ser phosphorylation site {S618} Ser phosphorylation site {S633} Ser phosphorylation site {S637} RNP motif NAME: RNP motif SITE: 653-729 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S701}

Database Correlations

OMIM 160994 UniProt P52272 Pfam PF00076 Entrez Gene 4670 Kegg hsa:4670

References

UniProt :accession P52272