heterogeneous nuclear ribonucleoprotein L; hnRNP L (HNRNPL HNRPL P/OKcl14)

Function: - heterogeneous nuclear ribonucleoprotein involved in processing of pre-mRNAs - associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes - several isoelectric forms of the L protein are probably the results of post-translational modifications - interacts with HNRPLL Structure: contains 3 RRM domain (RNA recognition motif)s Compartment: nucleus, nucleoplasm

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 589 aa MW = 64 kD COMPARTMENT: cell nucleus MOTIF: glycine-rich region {39-89} MOTIF: Ser phosphorylation site {S52} RNP motif NAME: RNP motif SITE: 102-176 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 193-270 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S298} proline-rich region SITE: 335-382 MOTIF: proline residue (SEVERAL) RNP motif NAME: RNP motif SITE: 382-456 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

OMIM correlations UniProt P14866 Pfam PF00076 Entrez Gene 3191

References

UniProt :accession P14866