heterogeneous nuclear ribonucleoprotein H2; hnRNP H2; FTP-3; heterogeneous nuclear ribonucleoprotein H'; hnRNP H' (HNRNPH2, FTP3, HNRPH2)

Function: - component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm - binds poly(rG) - interacts with TXNL4/DIM1 Structure: - contains 3 RRM domains (RNA recognition motifs) Compartment: nucleus, nucleoplasm Expression: expressed ubiquitously

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 449 aa MW = 49 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl RNP motif NAME: RNP motif SITE: 11-90 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S104} Thr phosphorylation site {T107} RNP motif NAME: RNP motif SITE: 111-188 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif domain {234-433} MOTIF: consensus repeat {234-249} RNP motif NAME: RNP motif SITE: 289-364 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S310} domain {354-392} consensus repeat {354-372} consensus repeat {374-392} consensus repeat {418-433}

Database Correlations

OMIM 300610 UniProt P55795 PFAM correlations Entrez Gene 3188 Kegg hsa:3188

References

UniProt :accession P55795