heterogeneous nuclear ribonucleoprotein F; hnRNP F; nucleolin-like protein mcs94-1; contains: heterogeneous nuclear ribonucleoprotein F, N-terminally processed (HNRNPF, HNRPF)

Function: - component of heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm - role in regulation of alternative splicing events - binds G-rich sequences in pre-mRNAs & keeps target RNA in an unfolded state - phosphorylated upon DNA damage, probably by ATM or ATR - sumoylated - identified in the spliceosome C complex - interacts with TBP & TXNL4/DIM1 Structure: - the N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA - contains 3 RRM domains (RNA recognition motifs) Compartment: nucleus, nucleoplasm Expression: expressed ubiquitously

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 415 aa MW = 46 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl RNP motif NAME: RNP motif SITE: 13-85 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif arginine residue {16} tryptophan residue {20} arginine residue {52} arginine residue {75} RNA interaction {81-86} Ser phosphorylation site {S104} RNP motif NAME: RNP motif SITE: 111-188 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif arginine residue {116} phenylalanine residue {120} lysine residue {150} Ser phosphorylation site {S161} lysine residue {173} RNA interaction {179-184} Ser phosphorylation site {S187} Tyr phosphorylation site {Y246} RNP motif NAME: RNP motif SITE: 289-366 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif arginine residue {294} tyrosine residue {298} Ser phosphorylation site {S310} arginine residue {326} arginine residue {349} RNA interaction {355-360}

Database Correlations

OMIM 601037 UniProt P52597 PFAM correlations Entrez Gene 3185 Kegg hsa:3185

References

UniProt :accession P52597