heterogeneous nuclear ribonucleoprotein-C1/C2 (hnRNP-C1/C2)

Function: - binds pre-mRNA & nucleates assembly of 40S hnRNP particles - single HNRNPC tetramers bind 230-240 nucleotides - trimers of HNRNPC tetramers bind 700 nucleotides - may play a role in early steps of spliceosome assembly & pre-mRNA splicing - interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA & modulates stability & the level of translation of bound mRNA molecules - phosphorylated on Ser-260 & Ser-299 in resting cells - phosphorylated on Ser-253 & on 1 Ser in the poly-Ser stretch at position 238 in response to hydrogen peroxide - sumoylated; sumoylation reduces affinity for mRNA - tetramer composed of 3 copies of isoform C1 & 1 copy of isoform C2 - assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers - component of the 40S hnRNP particle - identified in the spliceosome C complex Structure: - belongs to the RRM HNRPC family, RALY subfamily - contains 1 RRM domain (RNA recognition motif) Compartment: nucleus. Note: Component of ribonucleosomes Alternative splicing: named isoforms=4; C2, C1

Specific

hnRNP-C1 hnRNP-C2

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 306 aa MW = 34 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl RNP motif NAME: RNP motif SITE: 16-87 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S113} Ser phosphorylation site {S120} Ser phosphorylation site {S121} Ser phosphorylation site {S138} nuclear translocation signal {155-161} Ser phosphorylation site {S162} acidic region {181-303} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S233} Ser phosphorylation site {S238} Ser phosphorylation site {S239} Ser phosphorylation site {S240} Ser phosphorylation site {S241} Ser phosphorylation site {S253} Ser phosphorylation site {S260} Ser phosphorylation site {S299} Ser phosphorylation site {S306}

Database Correlations

OMIM 164020 UniProt P07910 Pfam PF00076 Entrez Gene 3183 Kegg hsa:3183

References

UniProt :accession P07910